PDF | The present study aims to evaluate the therapeutic properties of the medicinal plants (Vitex negundo, Aegle marmelos and Boswellia serrata) for their . Abstract To evaluate the anti-inflammatory activity of Vitex negundo (VN) leaf extract and its mechanism of action in experimental animals. Carrageenin induced. Abstract. The present study was undertaken to assess the anti-inflammatory effect of ethanolic extract of Vitex negundo roots in rats.

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Antioxidant and Antiinflammatory Activity of Vitex negundo.

All the respective grouped animals were injected with carrageenan 0. Gandevi GujaratIndia, Tel: Oxytocin was dissolved in distilled water to get a desired concentration. Stabilization of the Prussian blue colour in the determination of polyphenols. Histomorphological changes induced by Vitex negundo in albino rats.

Antioxidant and Antiinflammatory Activity of Vitex negundo.

For mechanism of anti-inflammatory activity: The Indian Forester Ethanolic leaf acitvity of VN in the form of suspension was fed orally in a volume of 10 mL kg -1 wt. Carrageenin induced edema in hind paw of rat as assay for anti-inflammatory drugs.


Group I received distilled water and served as control. This activity may be due to presence of active constituents like flavonoidstriterpenoids and alkaloids. It has been claimed to possess many medicinal properties Tandon, Two methods were employed to evaluate the negyndo activity as well as potentiation effect of phenylbutazone and Ibuprofen anti-inflammatory action by VN.

The test drug showed significant anti-inflammatory activity in dose dependant manner in both experimental models. The ethno medical use of V. Patel Road, Bilimora, D: An experimental evaluation of anticonvulsant activity of Vitex inflammattory.

Medicinal uses and biological activities of Vitex negundo.

The reduction in the volume displacement of hind foot in comparison to control was taken as anti-inflammatory effect. Flavonoids as anti-oxidants evaluated by in vitro and in situ liver chemiluminescence. It is also useful in leucoderma and blood disorders.

Absorbance of the resulting pink chromogen was recorded at nm.

The tissue damage then provokes inflammatory response by vitec production of mediators and chemotactic factors 4. It is concluded that hydroalcoholic leaves extract of Vitex negundo and Murraya koenigii can offer protection against carrageenan induced paw edema in rats.

Although, leaves of VN have been investigated for its anti-inflammatory activity in past Telang et al. The total polyphenols were estimated as gallic acid equivalents.


After 7 days drug treatment in cotton pellet granuloma method, mL of blood was inflammztory from inner canthus of eye from each animal using capillary tube, in a vial containing EDTA as an anticoagulant.

Procedure Thirty minutes after drug or test compound extracts administration, 0.

But it was only Telang et al. Oxytocin Sandoz and oestradiol valerate Sigma organon were also used for the present study. Oxidative damage and pathogenesis.

Antioxidant and Antiinflammatory Activity of Vitex negundo

Inflammahory mice of either sex, weighing gm were used to determine the lethal dose. International Journal of Pharmacology, 2: These findings were in agreement with the findings of Telang et al. Springer Science and Business Media, The clearance for the use of animals for experimental purpose was obtained from institutional ethical committee constituted for the purpose at M.